Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.58 |
| ▸ | MERTK | Q12866 | 6/20 | 0.58 |
| ▸ | PARP1 | P09874 | 4/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.48 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.46 |
| ▸ | MELK | Q14680 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18615786 | 0.88 | AXL (0.57) | AXLMERTKPARP1PIK3CBPARP2 | |
| SCHEMBL18615806 | 0.81 | AXL (0.62) | AXLMERTKPARP1PIK3CBPARP2 | |
| SCHEMBL21779412 | 0.81 | AXL (0.56) | AXLMERTKPIK3CBMAP3K11PIK3C3 | |
| SCHEMBL18615708 | 0.81 | AXL (0.62) | AXLMERTKPIK3CBPIK3C3 | |
| SCHEMBL18617157 | 0.79 | FYN (0.66) | AXLMERTKPIK3CBMAP3K11PIK3C3 | |
| SCHEMBL18615800 | 0.78 | AXL (0.56) | AXLMERTKPIK3CBCHEK1MAP3K11 | |
| SCHEMBL18616286 | 0.77 | MERTK (0.55) | AXLMERTKPIK3CBMAP3K11PIK3C3 | |
| SCHEMBL18615845 | 0.76 | AXL (0.62) | AXLMERTKMAP3K11PIK3C3FLT3 | |
| SCHEMBL16042922 | 0.75 | PARP1 (0.59) | PARP1PARP2PARP3CHRM3CHEK1 | |
| SCHEMBL31669248 | 0.75 | PARP1 (0.54) | AXLMERTKPARP1PARP2PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |
| WO-2017039331-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2017-03-09 | — | — | WO | disclosed |