Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18617437 | 0.85 | TNF (0.37) | TNFNOD2NOD1MPOTP53 | |
| SCHEMBL18617605 | 0.78 | PIK3CG (0.36) | MPOMAPTLMNANUDT1 | |
| SCHEMBL18585766 | 0.78 | MPO (0.33) | TNFNOD2NOD1MPO | |
| SCHEMBL18617433 | 0.65 | ALDH1A1 (0.55) | TP53MAPTKMT2ALMNA | |
| SCHEMBL18617402 | 0.65 | MPO (0.33) | MPOMAPTKMT2AMEN1NR4A2 | |
| SCHEMBL18617601 | 0.64 | MAPT (0.33) | TNFNOD2NOD1MPOMAPT | |
| SCHEMBL102270 | 0.64 | PSMB8 (0.36) | MAPTPRMT5ADORA1LMNA | |
| SCHEMBL203092 | 0.61 | PSMB8 (0.37) | PRMT5 | |
| SCHEMBL18617398 | 0.61 | GRM2 (0.43) | LMNA | |
| SCHEMBL25232905 | 0.61 | PSMB8 (0.36) | MAPTKMT2AGAAPRMT5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040449-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |