Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.31 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.31 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.31 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186318 | 0.93 | CNR2 (0.37) | CNR2CNR1KCNQ3KCNQ2P2RX7 | |
| SCHEMBL186731 | 0.92 | CNR2 (0.35) | CNR2OPRL1MAPK3MAPK1P2RX7 | |
| SCHEMBL185111 | 0.87 | CNR2 (0.36) | CNR2OPRL1MAPK3MAPK1AURKA | |
| SCHEMBL13128909 | 0.85 | CNR2 (0.37) | CNR2OPRL1MAPK3MAPK1CNR1 | |
| SCHEMBL185024 | 0.85 | OPRL1 (0.36) | CNR2OPRL1CNR1AURKAKCNQ3 | |
| Hydrochloric Acid SCHEMBL2805208 | 0.85 | CNR2 (0.36) | CNR2OPRL1MAPK3MAPK1CNR1 | |
| SCHEMBL2809028 | 0.81 | P2RX7 (0.38) | CNR2CNR1AURKAHDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL2805860 | 0.81 | P2RX7 (0.38) | CNR2CNR1AURKAHDAC3HDAC1 | |
| SCHEMBL185877 | 0.80 | P2RX7 (0.36) | CNR2P2RX7RAF1 | |
| SCHEMBL15455029 | 0.78 | CNR2 (0.38) | CNR2CNR1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |