Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 5/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2809565 | 0.87 | P2RX7 (0.37) | P2RX7PTGS2CNR2PTGESJAK1 | |
| SCHEMBL186731 | 0.87 | CNR2 (0.35) | P2RX7CNR2 | |
| SCHEMBL14856842 | 0.85 | P2RX7 (0.34) | P2RX7PTGS2CNR2PTGESEGFR | |
| SCHEMBL14865362 | 0.83 | P2RX7 (0.37) | P2RX7PTGS2CNR2PTGESJAK1 | |
| SCHEMBL185468 | 0.82 | PTGS2 (0.39) | P2RX7PTGS2CNR2 | |
| SCHEMBL186318 | 0.81 | CNR2 (0.37) | P2RX7CNR2 | |
| SCHEMBL186186 | 0.80 | CNR2 (0.35) | P2RX7CNR2RAF1 | |
| SCHEMBL2810139 | 0.80 | BDKRB1 (0.36) | P2RX7PTGS2CNR2PTGESEGFR | |
| SCHEMBL14865329 | 0.79 | P2RX7 (0.34) | P2RX7PTGS2CNR2PTGESJAK1 | |
| SCHEMBL185693 | 0.78 | FGFR4 (0.33) | P2RX7PTGESJAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |