Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 12/20 | 0.58 |
| ▸ | TPO | P07202 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | EPX | P11678 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18586023 | 0.88 | MPO (0.60) | MPOTPOCYP3A4EPXDHFR | |
| SCHEMBL18620557 | 0.82 | MPO (0.53) | MPOTPOCYP3A4EPX | |
| SCHEMBL18586501 | 0.82 | DHFR (0.65) | MPODHFR | |
| SCHEMBL19381115 | 0.79 | DHFR (0.61) | DHFR | |
| SCHEMBL18617434 | 0.77 | MPO (0.40) | MPOTPOCYP3A4EPX | |
| SCHEMBL57463 | 0.77 | MPO (0.56) | MPOTPOCYP3A4EPX | |
| SCHEMBL10573498 | 0.77 | MPO (0.51) | MPOTPOCYP3A4EPX | |
| SCHEMBL18320057 | 0.77 | ADCY10 (0.48) | MPOTPOCYP3A4EPX | |
| SCHEMBL18618882 | 0.77 | MPO (0.69) | MPO | |
| SCHEMBL18616509 | 0.76 | MPO (0.39) | MPOTPOCYP3A4EPX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040451-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |