Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 12/20 | 0.55 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | AGXT | P21549 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18618928 | 0.89 | MPO (0.55) | MPO | |
| SCHEMBL18620324 | 0.83 | MPO (0.53) | MPO | |
| SCHEMBL18621108 | 0.82 | IDO1 (0.43) | MPOIDO1AGXTMAPK14 | |
| SCHEMBL18620093 | 0.80 | MPO (0.56) | MPO | |
| SCHEMBL18620321 | 0.80 | MPO (0.56) | MPO | |
| SCHEMBL18618877 | 0.78 | MPO (0.55) | MPO | |
| SCHEMBL18620054 | 0.76 | MPO (0.60) | MPO | |
| SCHEMBL18621229 | 0.76 | MPO (0.60) | MPO | |
| SCHEMBL18621231 | 0.75 | MPO (0.58) | MPO | |
| SCHEMBL18618819 | 0.74 | MPO (0.51) | MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040451-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |