Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 16/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | TPO | P07202 | 1/20 | 0.33 |
| ▸ | EPX | P11678 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18621231 | 0.87 | MPO (0.58) | MPO | |
| SCHEMBL18620046 | 0.82 | MPO (0.47) | MPOCXCR2 | |
| SCHEMBL18618928 | 0.80 | MPO (0.55) | MPOCHRM4 | |
| SCHEMBL18618929 | 0.80 | MPO (0.55) | MPO | |
| SCHEMBL18620321 | 0.78 | MPO (0.56) | MPOTPOEPX | |
| SCHEMBL18621233 | 0.78 | MPO (0.54) | MPOADORA2AADORA1 | |
| SCHEMBL18618877 | 0.77 | MPO (0.55) | MPO | |
| SCHEMBL18620324 | 0.76 | MPO (0.53) | MPOTPOEPX | |
| SCHEMBL18618819 | 0.76 | MPO (0.51) | MPOTPOEPX | |
| SCHEMBL18620054 | 0.74 | MPO (0.60) | MPOADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040451-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |