Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 14/20 | 0.51 |
| ▸ | TPO | P07202 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | EPX | P11678 | 1/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18620305 | 0.94 | MPO (0.55) | MPOTPOCYP3A4EPX | |
| SCHEMBL18618875 | 0.91 | MPO (0.55) | MPOTPOCYP3A4EPX | |
| SCHEMBL18621228 | 0.85 | MPO (0.55) | MPOTPOCYP3A4EPX | |
| SCHEMBL18618945 | 0.85 | RAB9A (0.41) | MPOTPOCYP3A4EPXRAB9A | |
| SCHEMBL18620324 | 0.85 | MPO (0.53) | MPOTPOCYP3A4EPX | |
| SCHEMBL18620321 | 0.84 | MPO (0.56) | MPOTPOCYP3A4EPXNPC1 | |
| SCHEMBL18618950 | 0.81 | MPO (0.56) | MPO | |
| SCHEMBL18618878 | 0.81 | MPO (0.56) | MPOTPOCYP3A4EPXNPC1 | |
| SCHEMBL18620320 | 0.81 | MPO (0.59) | MPOTPOCYP3A4EPX | |
| SCHEMBL18620322 | 0.81 | MPO (0.59) | MPOCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040451-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |