Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 12/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TPO | P07202 | 1/20 | 0.37 |
| ▸ | EPX | P11678 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18620075 | 0.87 | MPO (0.52) | MPOCYP3A4TPOEPX | |
| SCHEMBL18620324 | 0.85 | MPO (0.53) | MPOCYP3A4TPOEPX | |
| SCHEMBL18618819 | 0.85 | MPO (0.51) | RAB9AMPOCYP3A4TPOEPX | |
| SCHEMBL18618875 | 0.83 | MPO (0.55) | MPOMEN1KMT2ACYP3A4TPO | |
| SCHEMBL18620305 | 0.80 | MPO (0.55) | MPOCYP3A4TPOEPX | |
| SCHEMBL18618877 | 0.80 | MPO (0.55) | MPO | |
| SCHEMBL18621231 | 0.77 | MPO (0.58) | MPO | |
| SCHEMBL18620663 | 0.76 | MPO (0.56) | MPOCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL19363959 | 0.75 | MPO (0.36) | MPOKMT2ACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL18621233 | 0.72 | MPO (0.54) | MPOMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040451-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |