Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 6/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18619576 | 0.82 | PREP (0.42) | PREPKMT2ACCR1DPP4DPP8 | |
| SCHEMBL18619652 | 0.75 | PREP (0.53) | PREPFAPCCR1DPP4DPP8 | |
| SCHEMBL18620640 | 0.75 | MEN1 (0.47) | PREPKMT2AELANETAAR1 | |
| SCHEMBL20485170 | 0.75 | MEN1 (0.47) | PREPKMT2AELANETAAR1 | |
| SCHEMBL18619648 | 0.74 | PREP (0.55) | PREPFAPCCR1DPP4DPP8 | |
| SCHEMBL12949867 | 0.74 | PREP (0.41) | PREPFAPCCR1DPP4DPP8 | |
| SCHEMBL18619598 | 0.73 | ALDH1A1 (0.46) | PREPKMT2ACYP3A4ELANETAAR1 | |
| SCHEMBL22209534 | 0.73 | ALDH1A1 (0.46) | PREPKMT2ACYP3A4ELANETAAR1 | |
| SCHEMBL3181879 | 0.73 | PREP (0.52) | PREPKMT2ANPC1CYP3A4ELANE | |
| SCHEMBL8288972 | 0.72 | PREP (0.51) | PREPKMT2AFAPDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040304-A1 | MALT1 INHIBITORS AND USES THEREOF | CORNELL UNIVERSITY (US) | 2017-03-09 | — | — | WO | disclosed |