Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.32 |
| ▸ | TUBB | P07437 | 2/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.32 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13344922 | 0.79 | KDM4E (0.58) | KDM4EALDH1A1LMNAHPGDAXL | |
| SCHEMBL12596867 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1LMNAHPGDAXL | |
| SCHEMBL15850980 | 0.73 | AXL (0.39) | KDM4EALDH1A1LMNAHPGDAXL | |
| SCHEMBL25547290 | 0.72 | KDM4E (0.43) | KDM4EALDH1A1LMNAHPGDCYP19A1 | |
| SCHEMBL18639763 | 0.70 | MEN1 (0.38) | ALDH1A1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9315345 | 0.69 | ESR1 (0.41) | KDM4EALDH1A1LMNAHPGDAXL | |
| SCHEMBL18326948 | 0.67 | CYP19A1 (0.42) | KDM4EALDH1A1LMNAHPGDAXL | |
| SCHEMBL14234928 | 0.67 | KDM4E (0.57) | KDM4EALDH1A1LMNAHPGDCYP19A1 | |
| SCHEMBL14115029 | 0.65 | AXL (0.52) | ALDH1A1HPGDAXLCYP2A6CYP19A1 | |
| SCHEMBL28796378 | 0.65 | CYP2A6 (0.37) | LMNAHPGDCYP2A6KEAP1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170071907-A1 | THIENO-INDOLE MOIETIES AND METHODS OF TREATING USING THE SAME | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-03-16 | — | — | US | disclosed |
| US-20170071907-A1 | THIENO-INDOLE MOIETIES AND METHODS OF TREATING USING THE SAME | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170071907-A1 | THIENO-INDOLE MOIETIES AND METHODS OF TREATING USING THE SAME | INMT, TYMP, TOP1 | KDM4E 548/4885ALDH1A1 983/4885LMNA 1940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.