Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18625982 | 0.89 | NPC1 (0.40) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL16264765 | 0.85 | PDGFRB (0.44) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL19387101 | 0.83 | DRD2 (0.43) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL16263160 | 0.82 | NPC1 (0.42) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL18625821 | 0.77 | CYP19A1 (0.60) | NAMPTNPC1RAB9AMGAMGAA | |
| SCHEMBL18625968 | 0.75 | CYP19A1 (0.57) | NAMPTNPC1RAB9AMGAMGAA | |
| SCHEMBL30434942 | 0.73 | CA12 (0.46) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL29009129 | 0.73 | CA12 (0.46) | NPC1MAPTRAB9AALDH1A1PDGFRB | |
| SCHEMBL18625817 | 0.72 | NAMPT (0.41) | NAMPTNPC1RAB9AMGAMGAA | |
| SCHEMBL12304956 | 0.71 | TEK (0.55) | NAMPTNPC1RAB9AMGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771389-B2 | Tylosin derivatives and method for preparation thereof | THE KITASAKO INSTITUTE (JP) | 2017-09-26 | — | — | US | disclosed |
| US-9593140-B2 | Antibacterial tylosin derivatives and methods for their preparation | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2017-03-14 | — | — | US | disclosed |