Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metoclopramide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 known ✓ | Q13639 | 5/20 | 1.00 |
| ▸ | HTR3A known ✓ | P46098 | 2/20 | 1.00 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 1.00 |
| ▸ | DRD3 | P35462 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | HTR2B | P41595 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | HTR3B | O95264 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | MPO | P05164 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | DRD4 | P21917 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metoclopramide SCHEMBL27855472 | 1.00 | HTR4 (1.00) | HTR4CYP2D6CYP1A2ADRA2ADRD3 | |
| Metoclopramide SCHEMBL28222039 | 1.00 | HTR4 (1.00) | HTR4CYP2D6CYP1A2ADRA2ADRD3 | |
| Metoclopramide SCHEMBL8160010 | 0.99 | HTR4 (0.98) | HTR4CYP2D6CYP1A2ADRA2ADRD3 | |
| Metoclopramide SCHEMBL205200 | 0.99 | RAB9A (1.00) | HTR4CYP2D6CYP1A2ADRA2ADRD3 | |
| Metoclopramide SCHEMBL30571110 | 0.99 | RAB9A (1.00) | HTR4CYP2D6CYP1A2ADRA2ADRD3 | |
| Metoclopramide SCHEMBL10385638 | 0.99 | HTR4 (0.98) | HTR4CYP2D6CYP1A2ADRA2ADRD3 | |
| Metoclopramide SCHEMBL678940 | 0.99 | RAB9A (1.00) | HTR4CYP2D6CYP1A2ADRA2ADRD3 | |
| Metoclopramide SCHEMBL678957 | 0.98 | HTR4 (0.95) | HTR4CYP2D6CYP1A2ADRA2ADRD3 | |
| Metoclopramide SCHEMBL5012583 | 0.98 | RAB9A (0.98) | HTR4CYP2D6CYP1A2ADRA2ADRD3 | |
| Metoclopramide SCHEMBL6263013 | 0.98 | RAB9A (0.98) | HTR4CYP2D6CYP1A2ADRA2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 40415 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026099533-A1 | TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) WITH GPBP1 INHIBITORS | UNIVERSITAT DE VALÈNCIA (ES) | 2026-05-15 | — | — | WO | claimed |
| US-20260131089-A1 | DRUG DELIVERY DEVICES AND METHODS FOR ADMINISTERING SUBSTANCES TO A BODY CAVITY BY HETEROGENOUS AEROSOLIZATION FOR TREATMENT OF BINGE-EATING DISORDERS AND/OR OBESITY | APTARGROUP, INC. (US) | 2026-05-14 | — | — | US | claimed |
| WO-2026090164-A1 | COMPOSITIONS COMPRISING ELISMETREP AND A SECOND THERAPEUTIC AGENT FOR TREATING OR PREVENTING MIGRAINE OR PAIN | KALLYOPE, INC. (US) | 2026-04-30 | — | — | WO | claimed |
| WO-2026090593-A2 | RNA BIOMARKERS FOR USE IN BARRETT'S ESOPHAGUS | CITY OF HOPE (US) | 2026-04-30 | — | — | WO | claimed |
| US-20260115161-A1 | 2-HYDROXY-OCTADECENE-9-CIS-OATE FOR USE IN THE TREATMENT OF ONCOLOGICAL PATHOLOGIES AND NEUROPATHIC PAIN | LAMINAR PHARMACEUTICALS S A (ES) | 2026-04-30 | — | — | US | claimed |
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| EP-4724062-A2 | COMPOSITIONS AND METHODS FOR INCREASING EXPOSURE OF R(-)-MDA | EmpathBio, Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| EP-4725483-A1 | COMBINATION COMPRISING AT LEAST ONE 5-HT2A RECEPTOR ANTAGONIST AND AT LEAST ONE 5-HT3 RECEPTOR ANTAGONIST AND ITS MEDICAL USE | Université de Bordeaux (FR) | 2026-04-15 | — | — | EP | claimed |
| EP-4719552-A1 | INDUCTION OF GENERAL ANESTHESIA IN ADULTS UNDERGOING ELECTIVE SURGERY | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2026-04-08 | — | — | EP | claimed |
| US-20260090584-A1 | SYSTEMS AND METHODS FOR ESTIMATING AEROSOLIZATION EMISSION | SCIENTIFIC HORIZONS CONSULTING LLC (US) | 2026-04-02 | — | — | US | claimed |
| EP-0011489-B1 | AN ANALGESIC EFFERVESCENT POWDER AND PROCESS FOR ITS PREPARATION | BEECHAM GROUP PLC (GB) | 1982-12-15 | — | — | EP | claimed |
| EP-0011490-B1 | ANALGESIC TABLET AND PROCESS FOR ITS PREPARATION | BEECHAM GROUP PLC (GB) | 1982-11-03 | — | — | EP | claimed |
| US-4325971-A | ANALGESIC FOR HEADACHES | BEECHAM GROUP LIMITED (GB) | 1982-04-20 | — | — | US | claimed |
| US-4316897-A | TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | claimed |
| US-4309408-A | ACETAMINOPHEN AND METOCLOPRAMIDE; ANALGESIC FOR MIGRAINE HEADACHES | BEECHAM GROUP LIMITED (GB) | 1982-01-05 | — | — | US | claimed |
| US-4279836-A | Hydroxamic acid derivative and method of preparing metoclopramide using same | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1981-07-21 | — | — | US | claimed |
| US-4230717-A | METIAMIDE OR CEMETIDINE | LOVELACE ALAN M ADMINISTRATOR | 1980-10-28 | — | — | US | claimed |
| EP-0011490-A2 | Analgesic tablet and process for its preparation | BEECHAM GROUP PLC (GB) | 1980-05-28 | — | — | EP | claimed |
| EP-0011489-A1 | An analgesic effervescent powder and process for its preparation | BEECHAM GROUP PLC (GB) | 1980-05-28 | — | — | EP | claimed |
| US-4176180-A | Pharmaceutical composition comprising erythromycin and metoclopramide and method of preparing same | SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES (FR) | 1979-11-27 | — | — | US | claimed |