Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metoclopramide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 known ✓ | Q13639 | 5/20 | 0.98 |
| ▸ | HTR3A known ✓ | P46098 | 2/20 | 0.98 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.98 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.98 |
| ▸ | DRD3 | P35462 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 3/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | HTR3B | O95264 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | MPO | P05164 | 1/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.98 |
| ▸ | DRD4 | P21917 | 1/20 | 0.98 |
| ▸ | HTR2A | P28223 | 1/20 | 0.98 |
| ▸ | HTR2C | P28335 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metoclopramide SCHEMBL678940 | 1.00 | RAB9A (1.00) | RAB9AHTR4CYP2D6CYP1A2ADRA2A | |
| Metoclopramide SCHEMBL30571110 | 1.00 | RAB9A (1.00) | RAB9AHTR4CYP2D6CYP1A2ADRA2A | |
| Metoclopramide SCHEMBL133509 | 0.99 | RAB9A (0.98) | RAB9AHTR4CYP2D6CYP1A2ADRA2A | |
| Metoclopramide SCHEMBL6263013 | 0.99 | RAB9A (0.98) | RAB9AHTR4CYP2D6CYP1A2ADRA2A | |
| Metoclopramide SCHEMBL18614363 | 0.99 | RAB9A (0.98) | RAB9AHTR4CYP2D6CYP1A2ADRA2A | |
| Metoclopramide SCHEMBL6569231 | 0.99 | RAB9A (0.98) | RAB9AHTR4CYP2D6CYP1A2ADRA2A | |
| Metoclopramide SCHEMBL5012583 | 0.99 | RAB9A (0.98) | RAB9AHTR4CYP2D6CYP1A2ADRA2A | |
| Metoclopramide SCHEMBL18629 | 0.99 | HTR4 (1.00) | RAB9AHTR4CYP2D6CYP1A2ADRA2A | |
| Metoclopramide SCHEMBL27855472 | 0.99 | HTR4 (1.00) | RAB9AHTR4CYP2D6CYP1A2ADRA2A | |
| Metoclopramide SCHEMBL28222039 | 0.99 | HTR4 (1.00) | RAB9AHTR4CYP2D6CYP1A2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 394 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240390364-A1 | Novel Pyridine Compositions and their use in methods for preventing or treating diseases, disorders and conditions | REID CHRISTOPHER BRIAN (US) | 2024-11-28 | — | — | US | claimed |
| CN-117770408-A | Mixed fruit pulp and preparation process and application thereof | 齐鲁工业大学(山东省科学院) | 2024-03-29 | — | — | CN | claimed |
| US-20240041773-A1 | POWDER MIXING DEVICE, AND USES THEREOF | UNIV CONNECTICUT (US) | 2024-02-08 | — | — | US | claimed |
| US-9616031-B2 | Method for encapsulating particles | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2017-04-11 | — | — | US | claimed |
| EP-2642984-B1 | METHOD FOR ENCAPSULATING PARTICLES | UNIV NANYANG TECH (SG) | 2017-01-11 | — | — | EP | claimed |
| US-20160257952-A1 | IDENTIFICATION OF STRUCTURALLY SIMILAR SMALL MOLECULES THAT ENHANCE THERAPEUTIC EXON SKIPPING | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-08 | — | — | US | claimed |
| US-9381163-B2 | Floating capsules encapsulating particles loaded with one or more drugs | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2016-07-05 | — | — | US | claimed |
| US-20160120828-A1 | COLONOSCOPY PREPARATION KIT | ASCLEMED USA INC DBA ENOVACHEM MFG (US) | 2016-05-05 | — | — | US | claimed |
| US-20150164815-A1 | FLOATING CAPSULES ENCAPSULATING PARTICLES LOADED WITH ONE OR MORE DRUGS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2015-06-18 | — | — | US | claimed |
| US-20130302429-A1 | METHOD FOR ENCAPSULATING PARTICLES | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2013-11-14 | — | — | US | claimed |
| CN-101674815-A | Transdermal therapeutic system for administering water-soluble active ingredients | LOHMANN THERAPIE SYST LTS | 2010-03-17 | — | — | CN | claimed |
| US-7678762-B2 | Methods for reducing the risk of hypoglycemia | DIOBEX, INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1814558-A2 | METHODS AND COMPOSITIONS FOR REDUCING NEURODEGENERATION IN AMYOTROPHIC LATERAL SCLEROSIS | Yoo, Seo Hong (US) | 2007-08-08 | — | — | EP | claimed |
| US-20060142241-A1 | Methods and compositions for reducing neurodegeneration in amyotrophic lateral sclerosis | YOO SEO H | 2006-06-29 | — | — | US | claimed |
| WO-2006050165-A2 | METHODS AND COMPOSITIONS FOR REDUCING NEURODEGENERATION IN AMYOTROPHIC LATERAL SCLEROSIS | YOO SEO HONG (US) | 2006-05-11 | — | — | WO | claimed |
| EP-1357916-A2 | TWO-COMPONENT ANTI-EMETIC COMPOSITION COMPRISING DEXAMETHASONE AND METOCLOPRAMIDE | Odyssey Pharmaceuticals LLC (US) | 2003-11-05 | — | — | EP | claimed |
| EP-0711152-B1 | POWDER-LAYERED ORAL DOSAGE FORMS | EURO CELTIQUE SA (LU) | 2002-12-04 | — | — | EP | claimed |
| US-20020055495-A1 | Two-component anti-emetic composition | ODYSSEY PHARMACEUTICALS, LLC | 2002-05-09 | — | — | US | claimed |
| WO-2002020001-A2 | TWO-COMPONENT ANTI-EMETIC COMPOSITION COMPRISING DEXAMETHASONE AND METOCLOPRAMIDE | ODYSSEY PHARMACEUTICALS LLC (US) | 2002-03-14 | — | — | WO | claimed |
| US-5977174-A | Cholinergic compositions and uses thereof | NEUROMEDICA, INC. (US) | 1999-11-02 | — | — | US | claimed |