Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | KIT | P10721 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | FLT1 | P17948 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12798698 | 0.76 | JAK2 (0.50) | JAK2CYP2C9CYP3A4CYP2C19KIT | |
| SCHEMBL21886177 | 0.75 | GPR84 (0.46) | SLC6A4MAP4K4FGFR1MAP2K1HIPK2 | |
| SCHEMBL24781572 | 0.73 | JAK2 (0.50) | JAK2CYP2C9CYP3A4CYP2C19KIT | |
| SCHEMBL12573415 | 0.71 | JAK2 (0.40) | JAK2CYP2C9CYP3A4CYP2C19KIT | |
| SCHEMBL12657250 | 0.71 | JAK2 (0.40) | JAK2CYP2C9CYP3A4CYP2C19KIT | |
| SCHEMBL17873349 | 0.70 | JAK2 (0.44) | JAK2CYP2C9CYP3A4CYP2C19KIT | |
| SCHEMBL14883424 | 0.68 | JAK2 (0.54) | JAK2CYP2C9CYP3A4CYP2C19BRAF | |
| SCHEMBL19710201 | 0.67 | JAK2 (0.50) | JAK2CYP2C9CYP3A4CYP2C19KIT | |
| SCHEMBL17873389 | 0.66 | JAK2 (0.46) | JAK2CYP2C9CYP3A4CYP2C19KIT | |
| SCHEMBL25493847 | 0.66 | JAK2 (0.46) | JAK2CYP2C9CYP3A4CYP2C19KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3141548-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES | Vertex Pharmaceuticals Incorporated (US) | 2017-03-15 | — | — | EP | disclosed |