Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NOTCH1 | P46531 | 2/20 | 0.36 |
| ▸ | NOTCH3 | Q9UM47 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15619970 | 0.85 | DAO (0.41) | DAOPOLBCREBBPAGTR1MAPT | |
| SCHEMBL15620367 | 0.85 | DAO (0.41) | DAOPOLBCREBBPAGTR1MAPT | |
| SCHEMBL4415153 | 0.79 | LRRK2 (0.41) | CREBBPAGTR1MEN1KMT2APGR | |
| SCHEMBL24112725 | 0.74 | ALDH1A1 (0.43) | DAOPOLBCREBBPAGTR1BRD4 | |
| SCHEMBL24112230 | 0.74 | ALDH1A1 (0.43) | DAOPOLBCREBBPAGTR1BRD4 | |
| SCHEMBL15619572 | 0.71 | TDP2 (0.46) | DAOCREBBPPARP1PGR | |
| SCHEMBL6307606 | 0.70 | PGR (0.42) | CREBBPAGTR1MEN1KMT2APGR | |
| SCHEMBL23769413 | 0.70 | NOTCH1 (0.52) | DAOPOLBMAPTKDM4EALOX15 | |
| SCHEMBL24112727 | 0.70 | PGR (0.53) | MEN1KMT2APGR | |
| SCHEMBL2263637 | 0.70 | PGR (0.53) | MEN1KMT2APGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897938-B1 | FLUOROALKYL DIBENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-15 | — | — | EP | disclosed |