Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 3/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17364632 | 0.88 | CFTR (0.43) | MAPTKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL2723272 | 0.81 | KDM4E (0.47) | MAPTKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL22981650 | 0.74 | ALPL (0.43) | KDM4EDHODHTGFBR1ALPLGAA | |
| SCHEMBL29707102 | 0.74 | ALPL (0.43) | KDM4EDHODHTGFBR1ALPLGAA | |
| SCHEMBL12302078 | 0.74 | MAPT (0.55) | MAPTKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL18634896 | 0.73 | MAPK1 (0.37) | MAPTKDM4EALDH1A1MAPK1ALPL | |
| SCHEMBL3780170 | 0.72 | MAPT (0.63) | MAPTKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL23703855 | 0.71 | KDM4E (0.47) | MAPTKDM4ENPC1ALDH1A1MAPK1 | |
| SCHEMBL1550266 | 0.71 | CFTR (0.48) | MAPTKDM4EALDH1A1CFTRGAA | |
| SCHEMBL24525066 | 0.70 | CFTR (0.51) | MAPTKDM4EALDH1A1CFTRDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632269-B1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONES AS CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2017-03-15 | — | — | EP | disclosed |