Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18634892 | 0.88 | MAPT (0.43) | CFTRMAPTKDM4ETGFBR1NPC1 | |
| SCHEMBL2723272 | 0.80 | KDM4E (0.47) | CFTRMAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL2731833 | 0.78 | CFTR (0.40) | CFTRMAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL1819192 | 0.74 | MAPT (0.53) | CFTRMAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL22981650 | 0.73 | ALPL (0.43) | KDM4ETGFBR1ALPLGAAPOLB | |
| SCHEMBL29707102 | 0.73 | ALPL (0.43) | KDM4ETGFBR1ALPLGAAPOLB | |
| SCHEMBL2731915 | 0.72 | CD274 (0.35) | MAPTKDM4EALDH1A1MAPK1ALPL | |
| SCHEMBL3780170 | 0.71 | MAPT (0.63) | CFTRMAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL12302078 | 0.71 | MAPT (0.55) | CFTRMAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL1550266 | 0.70 | CFTR (0.48) | CFTRMAPTKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632269-B1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONES AS CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9221834-B2 | Cyclic amine substituted oxazolidinone CETP inhibitor | MERCK SHARP & DOHME CORP. (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221834-B2 | Cyclic amine substituted oxazolidinone CETP inhibitor | MERCK SHARP & DOHME CORP. (US) | 2015-12-29 | — | — | US | disclosed |