Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507186 | 0.78 | PDE10A (0.43) | TRPV4CYP19A1APLNRGABRA1GABRG2 | |
| SCHEMBL23262834 | 0.78 | GRM5 (0.35) | TRPV4APLNRRAB9AGRM5GABRA1 | |
| SCHEMBL16132531 | 0.78 | HSD11B1 (0.37) | TRPV4CYP19A1APLNRUSP2RAB9A | |
| SCHEMBL2568687 | 0.75 | GRM5 (0.33) | TRPV4APLNRGRM5GABRA5 | |
| SCHEMBL229945 | 0.75 | TRPV4 (0.60) | TRPV4GRM5KDM4E | |
| SCHEMBL12001529 | 0.74 | KCNH2 (0.35) | TRPV4CYP19A1APLNRGABRA1GABRG2 | |
| SCHEMBL4729458 | 0.73 | TRPV4 (0.37) | TRPV4APLNRGRM5PDE10AKDM4E | |
| SCHEMBL30087636 | 0.72 | KCNN4 (0.41) | TRPV4APLNRGABRA5F2PRSS1 | |
| SCHEMBL17586504 | 0.71 | TRPV4 (0.40) | TRPV4APLNRGRM5PDE10ATRPA1 | |
| SCHEMBL19086840 | 0.71 | TRPV4 (0.40) | TRPV4GRM5TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978759-B1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES INC (US) | 2017-03-15 | — | — | EP | disclosed |