Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24406297 | 0.85 | OPRM1 (0.55) | HTR2AHRH1SLC22A1OPRM1SLC6A4 | |
| SCHEMBL882235 | 0.85 | OPRM1 (0.55) | HTR2AHRH1SLC22A1OPRM1SLC6A4 | |
| SCHEMBL12438398 | 0.85 | OPRM1 (0.55) | HTR2AHRH1SLC22A1OPRM1SLC6A4 | |
| SCHEMBL19072669 | 0.83 | HTR2A (0.44) | HTR2AHRH1AOC3SLC22A1OPRM1 | |
| SCHEMBL23138901 | 0.82 | HTR2A (0.64) | HTR2AHRH1OPRM1TAAR1CHRM2 | |
| SCHEMBL12300267 | 0.82 | HTR2A (0.64) | HTR2AHRH1OPRM1TAAR1CHRM2 | |
| SCHEMBL13958492 | 0.81 | ACHE (0.50) | AOC3TAAR1ACHECYP19A1ACP3 | |
| SCHEMBL18636472 | 0.81 | AOC3 (0.48) | HTR2AHRH1AOC3SLC6A2SLC6A4 | |
| SCHEMBL18636253 | 0.81 | AOC3 (0.48) | HTR2AHRH1AOC3SLC6A2SLC6A4 | |
| SCHEMBL18636543 | 0.80 | HTR2A (0.41) | HTR2AHRH1SLC22A1OPRM1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519100-B1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS | MAPI PHARMA LTD (IL) | 2017-03-15 | — | — | EP | disclosed |