Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.55 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12438398 | 1.00 | OPRM1 (0.55) | OPRM1SLC22A1HTR2AHRH1CHRNB2 | |
| SCHEMBL24406297 | 1.00 | OPRM1 (0.55) | OPRM1SLC22A1HTR2AHRH1CHRNB2 | |
| SCHEMBL16069735 | 0.92 | OPRM1 (0.51) | OPRM1SLC22A1HTR2AHRH1CHRNB2 | |
| SCHEMBL18636201 | 0.85 | HTR2A (0.47) | OPRM1SLC22A1HTR2AHRH1SLC6A4 | |
| SCHEMBL21164589 | 0.84 | SLC22A1 (0.47) | OPRM1SLC22A1HTR2AHIF1ALMNA | |
| SCHEMBL2383072 | 0.84 | HIF1A (0.53) | OPRM1SLC22A1HTR2AHIF1ALMNA | |
| SCHEMBL19072669 | 0.82 | HTR2A (0.44) | OPRM1SLC22A1HTR2AHRH1CYP3A4 | |
| SCHEMBL8757897 | 0.81 | OPRM1 (0.53) | OPRM1SLC22A1HTR2AHRH1CHRNB2 | |
| SCHEMBL12300267 | 0.80 | HTR2A (0.64) | OPRM1HTR2AHRH1LMNATSHR | |
| SCHEMBL23138901 | 0.80 | HTR2A (0.64) | OPRM1HTR2AHRH1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3868739-B1 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | GRUENENTHAL GMBH (DE) | 2023-10-04 | — | — | EP | disclosed |
| EP-3210965-B1 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | GRUENENTHAL GMBH (DE) | 2021-11-17 | — | — | EP | disclosed |
| EP-3210965-A1 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | Grünenthal GmbH (DE) | 2017-08-30 | — | — | EP | disclosed |
| EP-2368871-B1 | Process for the preperation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol | GRUENENTHAL GMBH (DE) | 2017-03-22 | — | — | EP | disclosed |
| WO-2012038974-A1 | PROCESS FOR PREPARING L-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVE | IND-SWIFT LABORATORIES LIMITED (IN) | 2012-03-29 | — | — | WO | disclosed |