Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12604978 | 1.00 | HRH4 (0.54) | HRH4NR1H2NR1H3KCNH2HRH3 | |
| SCHEMBL18601606 | 0.90 | HRH4 (0.57) | HRH4KCNH2HRH3 | |
| SCHEMBL18601607 | 0.90 | HRH4 (0.57) | HRH4KCNH2HRH3 | |
| SCHEMBL18636768 | 0.82 | LMNA (0.47) | HRH4NR1H2NR1H3RETAURKA | |
| SCHEMBL18636767 | 0.82 | LMNA (0.47) | HRH4NR1H2NR1H3RETAURKA | |
| SCHEMBL12604962 | 0.82 | LMNA (0.47) | HRH4NR1H2NR1H3RETAURKA | |
| SCHEMBL3211110 | 0.81 | HRH4 (0.54) | HRH4NR1H2NR1H3HRH3 | |
| SCHEMBL18636769 | 0.77 | HRH4 (0.69) | HRH4KCNH2HRH3AURKAPDPK1 | |
| SCHEMBL12604980 | 0.76 | HRH4 (0.60) | HRH4KCNH2HRH3AURKAPDPK1 | |
| SCHEMBL23855422 | 0.75 | PIK3CD (0.38) | HRH4NR1H2NR1H3RETAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |