Sugi Predict

Sugi Predict / Compounds / SCHEMBL23855422

SCHEMBL23855422

SCHEMBL23855422

Cc1nn(C)cc1-c1cc(N2CC3CCCN(C(=O)OC(C)(C)C)C3C2)nc(N)n1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 3/20 0.38
▸ AURKA O14965 4/20 0.38
▸ PDPK1 O15530 4/20 0.38
▸ AURKB Q96GD4 4/20 0.38
▸ NR1H2 P55055 1/20 0.38
▸ NR1H3 Q13133 1/20 0.38
▸ HRH4 Q9H3N8 2/20 0.37
▸ RET P07949 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ GPR119 Q8TDV5 2/20 0.33
▸ PIK3CA P42336 2/20 0.33
▸ RAF1 P04049 1/20 0.33
▸ ALOX5AP P20292 1/20 0.33
▸ FEN1 P39748 1/20 0.33
▸ PIK3R2 O00459 1/20 0.33
▸ PIK3R1 P27986 1/20 0.33
▸ PIK3CG P48736 1/20 0.33
▸ HSD11B1 P28845 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23855371 0.88 HRH4 (0.40) PIK3CDHRH4RAF1PIK3R2PIK3R1
SCHEMBL3211110 0.82 HRH4 (0.54) NR1H2NR1H3HRH4
SCHEMBL18636767 0.81 LMNA (0.47) AURKAPDPK1AURKBNR1H2NR1H3
SCHEMBL12604962 0.81 LMNA (0.47) AURKAPDPK1AURKBNR1H2NR1H3
SCHEMBL18636768 0.81 LMNA (0.47) AURKAPDPK1AURKBNR1H2NR1H3
SCHEMBL23869607 0.76 AAK1 (0.43) PIK3CDAURKAPDPK1AURKBHRH4
SCHEMBL12604978 0.75 HRH4 (0.54) AURKAPDPK1AURKBNR1H2NR1H3
SCHEMBL18636601 0.75 HRH4 (0.54) AURKAPDPK1AURKBNR1H2NR1H3
SCHEMBL23855381 0.72 HRH4 (0.60) HRH4
SCHEMBL23855430 0.70 HRH4 (0.39) AURKAPDPK1AURKBHRH4RAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3867248-B1 PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS NXERA PHARMA UK LTD (GB) 2025-12-10 — — EP disclosed
US-20250115587-A1 PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS NXERA PHARMA UK LIMITED (GB) 2025-04-10 — — US disclosed
US-12234227-B2 Pyrazole derivatives as H4 antagonist compounds NXERA PHARMA UK LIMITED (GB) 2025-02-25 — — US disclosed
US-20210300906-A1 PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS NXERA PHARMA UK LIMITED (GB) 2021-09-30 — — US disclosed
US-20210300906-A1 PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS NXERA PHARMA UK LIMITED (GB) 2021-09-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12234227-B2 Pyrazole derivatives as H4 antagonist compounds HRH4, HRH3, HRH2 PIK3CD 4342/4885AURKA 2307/4885PDPK1 2587/4885
US-20210300906-A1 PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS HRH4, HRH3, HDAC3 PIK3CD 4223/4885AURKA 2786/4885PDPK1 2122/4885
US-20250115587-A1 PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS HRH4, HRH3, HDAC3 PIK3CD 4223/4885AURKA 2786/4885PDPK1 2122/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.