Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18636767 | 1.00 | LMNA (0.47) | LMNANR1H2NR1H3HSP90AA1HSP90AB1 | |
| SCHEMBL12604962 | 1.00 | LMNA (0.47) | LMNANR1H2NR1H3HSP90AA1HSP90AB1 | |
| SCHEMBL3211110 | 0.87 | HRH4 (0.54) | NR1H2NR1H3HRH4 | |
| SCHEMBL5152986 | 0.84 | LMNA (0.48) | LMNAHRH4CYP1A2CYP2D6MAPT | |
| SCHEMBL5152980 | 0.84 | LMNA (0.48) | LMNAHRH4CYP1A2CYP2D6MAPT | |
| SCHEMBL18636601 | 0.82 | HRH4 (0.54) | NR1H2NR1H3AURKAPDPK1AURKB | |
| SCHEMBL12604978 | 0.82 | HRH4 (0.54) | NR1H2NR1H3AURKAPDPK1AURKB | |
| SCHEMBL23855422 | 0.81 | PIK3CD (0.38) | LMNANR1H2NR1H3AURKAPDPK1 | |
| SCHEMBL653782 | 0.76 | NR1H2 (0.48) | NR1H2NR1H3ALDH1A1GPR119RET | |
| SCHEMBL653780 | 0.76 | NR1H2 (0.48) | NR1H2NR1H3ALDH1A1GPR119RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |