Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18623892 | 0.83 | CES2 (0.42) | RAB9AKDM4ENPC1SMN1; SMN2LMNA | |
| SCHEMBL18636671 | 0.79 | TDP1 (0.40) | RAB9AKDM4ENPC1SMN1; SMN2TAAR1 | |
| SCHEMBL17169104 | 0.76 | CES2 (0.38) | RAB9AKDM4ENPC1SMN1; SMN2LMNA | |
| SCHEMBL17169289 | 0.74 | CES2 (0.34) | RAB9AKDM4ENPC1SMN1; SMN2LMNA | |
| SCHEMBL17169101 | 0.73 | KDM4E (0.49) | RAB9AKDM4ENPC1SMN1; SMN2NPSR1 | |
| SCHEMBL28882937 | 0.73 | KDM4E (0.49) | RAB9AKDM4ENPC1SMN1; SMN2NPSR1 | |
| SCHEMBL18683160 | 0.69 | TAAR1 (0.41) | RAB9AKDM4ENPC1SMN1; SMN2NPSR1 | |
| SCHEMBL18517369 | 0.69 | TAAR1 (0.41) | RAB9AKDM4ENPC1SMN1; SMN2NPSR1 | |
| SCHEMBL15705136 | 0.69 | CES2 (0.39) | RAB9AKDM4ENPC1SMN1; SMN2LMNA | |
| SCHEMBL17169282 | 0.68 | ADRB2 (0.36) | RAB9AADRB2ADRB1ADRB3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170073337-A1 | DIHYDROTHIAZINE AND DIHYDROOXAZINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170073337-A1 | DIHYDROTHIAZINE AND DIHYDROOXAZINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | BACE1, BACE2, APP | RAB9A 2112/4885KDM4E 2950/4885NPC1 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.