SCHEMBL186384

SCHEMBL186384

Cc1ccc(-c2cc(-c3ccc(C)cc3C)c(C=O)[nH]2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.41
KMT2A Q03164 5/20 0.41
RAB9A P51151 3/20 0.41
KDM4E B2RXH2 3/20 0.41
HPGD P15428 2/20 0.41
ALDH1A1 P00352 2/20 0.41
NPC1 O15118 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
LMNA P02545 1/20 0.41
MAPK1 P28482 1/20 0.41
MAPT P10636 3/20 0.41
GAA P10253 2/20 0.41
CTSV O60911 1/20 0.37
CTSL P07711 1/20 0.37
BIRC5 O15392 1/20 0.37
GCGR P47871 1/20 0.36
MAPK14 Q16539 1/20 0.36
CCNB2 O95067 1/20 0.36
CDK1 P06493 1/20 0.36
CCNB1 P14635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL187180 0.89 GCGR (0.38) MEN1KMT2ARAB9AKDM4EHPGD
SCHEMBL186558 0.88 MEN1 (0.38) MEN1KMT2ARAB9AKDM4EHPGD
SCHEMBL186020 0.84 MAPT (0.42) KMT2ARAB9AKDM4EALDH1A1NPC1
SCHEMBL186808 0.77 GCGR (0.43) MEN1KMT2ARAB9AKDM4EHPGD
SCHEMBL24940611 0.68 GAA (0.42) MEN1KMT2ARAB9AALDH1A1NPC1
SCHEMBL185969 0.68 NPC1 (0.53) RAB9AKDM4EHPGDALDH1A1NPC1
SCHEMBL2012266 0.68 CYP2A6 (0.56) MEN1KMT2ARAB9AKDM4EHPGD
SCHEMBL284409 0.68 ESR2 (0.47) MEN1KMT2ARAB9AALDH1A1NPC1
SCHEMBL29038580 0.68 MAPT (0.48) MEN1KMT2ARAB9AALDH1A1NPC1
SCHEMBL3043421 0.67 TDP1 (0.52) MEN1KMT2ARAB9AALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8778510-B2 Pyrromethene-boron complex compounds and organic electroluminescent elements using same IDEMITSU KOSAN CO., LTD. (JP) 2014-07-15 US disclosed
EP-2402351-B1 PYRROMETHENE-BORON COMPLEX COMPOUNDS AND ORGANIC ELECTRO- LUMINESCENT ELEMENTS USING SAME IDEMITSU KOSAN CO (JP) 2013-10-09 EP disclosed
US-20120037890-A1 PYRROMETHENE-BORON COMPLEX COMPOUNDS AND ORGANIC ELECTROLUMINESCENT ELEMENTS USING SAME MITSUI CHEMICALS, INC. 2012-02-16 US disclosed
EP-2402351-A1 PYRROMETHENE-BORON COMPLEX COMPOUNDS AND ORGANIC ELECTRO- LUMINESCENT ELEMENTS USING SAME Idemitsu Kosan Co., Ltd. (JP) 2012-01-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120037890-A1 PYRROMETHENE-BORON COMPLEX COMPOUNDS AND ORGANIC ELECTROLUMINESCENT ELEMENTS USING SAME LEF1, ZRANB2, AFF1 MEN1 243/4885KMT2A 1733/4885RAB9A 1128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.