Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 15/20 | 0.35 |
| ▸ | IL1B | P01584 | 6/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1863877 | 0.82 | — | — | |
| SCHEMBL1609577 | 0.82 | RORC (0.33) | — | |
| SCHEMBL562058 | 0.80 | MEN1 (0.31) | — | |
| SCHEMBL1863879 | 0.76 | P2RX7 (0.35) | P2RX7IL1BCYP2D6CHRM2CHRM1 | |
| SCHEMBL306555 | 0.74 | CYP2D6 (0.50) | P2RX7IL1BCYP2D6CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL4278081 | 0.74 | CHRM2 (0.35) | CHRM2CHRM1CHRM3 | |
| SCHEMBL2696109 | 0.73 | CYP2D6 (0.52) | CYP2D6 | |
| SCHEMBL1700488 | 0.71 | HSD11B1 (0.32) | — | |
| SCHEMBL562471 | 0.71 | HSD11B1 (0.32) | — | |
| SCHEMBL561927 | 0.71 | HSD11B1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376197-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2011068560-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |
| WO-2010138588-A9 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-05-05 | — | — | WO | disclosed |