Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BCL9 | O00512 | 1/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.31 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18643350 | 0.91 | MET (0.39) | HDAC1HDAC8HDAC6METAXL | |
| SCHEMBL18639761 | 0.90 | ALOX15 (0.41) | ALDH1A1MEN1LMNAKMT2AATM | |
| SCHEMBL18643267 | 0.85 | HDAC1 (0.35) | HDAC1HDAC8HDAC6ATMTDP1 | |
| SCHEMBL892549 | 0.75 | MTNR1A (0.52) | ALDH1A1LMNAKMT2A | |
| SCHEMBL18639758 | 0.73 | CCNA2 (0.34) | CCNA2CDK2CCNA1HDAC6ALDH1A1 | |
| SCHEMBL892580 | 0.67 | MTNR1A (0.55) | ALDH1A1LMNA | |
| SCHEMBL12794113 | 0.67 | HDAC6 (0.46) | HDAC1HDAC8HDAC6METALDH1A1 | |
| SCHEMBL10274768 | 0.67 | MTNR1A (0.53) | ALDH1A1LMNA | |
| SCHEMBL892306 | 0.66 | SNCA (0.54) | ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL891522 | 0.65 | MTNR1A (0.55) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440550-B1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | UNIV LEUVEN KATH (BE) | 2017-03-15 | — | — | EP | disclosed |