Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18643355 | 0.78 | LMNA (0.36) | KMT2ALMNACYP3A4CYP2C19MAPT | |
| SCHEMBL18643345 | 0.75 | MAPT (0.52) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL18643083 | 0.75 | KDM4E (0.43) | NPC1RAB9AKMT2AL3MBTL1LMNA | |
| SCHEMBL18643092 | 0.74 | AKR1C3 (0.40) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL18643079 | 0.74 | KMT2A (0.51) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL18643073 | 0.74 | HDAC6 (0.49) | CA1CA2 | |
| SCHEMBL18642841 | 0.74 | SMN1; SMN2 (0.43) | RAB9ALMNASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL19114245 | 0.74 | KDM4E (0.45) | MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL18643359 | 0.74 | NOS2 (0.41) | L3MBTL1LMNASMN1; SMN2TSHRTDP1 | |
| SCHEMBL18643087 | 0.73 | P2RX7 (0.39) | KMT2AATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440550-B1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | UNIV LEUVEN KATH (BE) | 2017-03-15 | — | — | EP | disclosed |