Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR5A2 | O00482 | 1/20 | 0.49 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18646078 | 0.92 | NR5A2 (0.53) | NR5A2NR5A1GAAKMT2APOLB | |
| SCHEMBL18646077 | 0.90 | NR5A2 (0.52) | NR5A2NR5A1GAAKMT2AALDH1A1 | |
| SCHEMBL28004482 | 0.88 | NR5A2 (0.48) | NR5A2NR5A1GAAKMT2AALDH1A1 | |
| SCHEMBL27560100 | 0.80 | ALDH1A1 (0.46) | NR5A2NR5A1GAAKMT2APOLB | |
| SCHEMBL29282569 | 0.78 | ALDH1A1 (0.62) | GAAKMT2AMAPK1ALDH1A1TDP1 | |
| SCHEMBL6750845 | 0.75 | NR5A2 (0.48) | NR5A2NR5A1ALDH1A1KDM4ECYP2C19 | |
| SCHEMBL18646369 | 0.75 | NR5A2 (0.53) | NR5A2NR5A1GAAKMT2AALDH1A1 | |
| SCHEMBL23793643 | 0.73 | CA2 (0.46) | NR5A2NR5A1GAAKMT2APOLB | |
| SCHEMBL25111316 | 0.73 | POLB (0.54) | GAAKMT2AMAPK1POLBALDH1A1 | |
| SCHEMBL394716 | 0.72 | CA2 (0.45) | NR5A2NR5A1GAAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10980755-B2 | LRH-1 modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-04-20 | — | — | US | disclosed |
| WO-2017044889-A1 | LRH-1 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10980755-B2 | LRH-1 modulators | NR1H4, NR1H2, NR1H3 | NR5A2 11/4885NR5A1 27/4885GAA 4646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.