Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | VDR | P11473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12859465 | 1.00 | SYK (0.34) | SYKLMNAMAPK1CYP2C19HIF1A | |
| SCHEMBL25038990 | 0.81 | MAPK1 (0.43) | LMNAMAPK1CYP2C19SMN1; SMN2AAK1 | |
| SCHEMBL18999996 | 0.79 | LMNA (0.46) | LMNACYP2C19SMN1; SMN2 | |
| SCHEMBL12732931 | 0.79 | LMNA (0.45) | LMNACYP2C19HIF1ASMN1; SMN2 | |
| SCHEMBL12708575 | 0.76 | LMNA (0.36) | SYKLMNACYP2C19HIF1ASMN1; SMN2 | |
| SCHEMBL12871614 | 0.76 | HPGD (0.35) | LMNACYP2C19HIF1APRMT5WDR77 | |
| SCHEMBL19431118 | 0.76 | HPGD (0.39) | LMNACYP2C19HIF1ASMN1; SMN2EGFR | |
| SCHEMBL7755318 | 0.75 | TDP1 (0.42) | SYKLMNA | |
| SCHEMBL1222350 | 0.74 | TDP1 (0.49) | SYKLMNA | |
| SCHEMBL1222348 | 0.74 | TDP1 (0.49) | SYKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598432-B2 | 2,4-pyrimidinediamine compounds and uses as anti-proliferative agents | RIGEL PHARMACEUTICALS, INC. (US) | 2017-03-21 | — | — | US | disclosed |