Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | WDR5 | P61964 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.53 |
| ▸ | LDHA | P00338 | 1/20 | 0.53 |
| ▸ | CDC25B | P30305 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147050 | 0.81 | CDC25B (0.71) | HSD17B10MEN1KMT2ANR4A1NR4A2 | |
| SCHEMBL30519263 | 0.81 | CDC25B (0.71) | HSD17B10MEN1KMT2ANR4A1NR4A2 | |
| SCHEMBL16737157 | 0.79 | MEN1 (0.69) | HSD17B10MEN1KMT2ANR4A1NR4A2 | |
| SCHEMBL4593816 | 0.78 | CDC25B (0.61) | WDR5MEN1KMT2ANR4A1NR4A2 | |
| SCHEMBL31531051 | 0.78 | WDR5 (0.59) | HSD17B10WDR5MEN1KMT2ANR4A1 | |
| SCHEMBL11795612 | 0.77 | CDC25B (0.52) | WDR5MEN1KMT2ANR4A1NR4A2 | |
| SCHEMBL11799867 | 0.77 | CLCN2 (0.63) | MEN1KMT2ANR4A1NR4A2CDC25B | |
| SCHEMBL11799846 | 0.77 | FTO (0.58) | MEN1KMT2ANR4A1NR4A2NR4A3 | |
| SCHEMBL29061899 | 0.76 | HSD17B10 (0.53) | HSD17B10MEN1KMT2ACDC25BCYP3A4 | |
| SCHEMBL11690219 | 0.76 | GRIK1 (0.76) | HSD17B10MEN1KMT2ACDC25BGRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377784-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | WAKE FOREST UNIVERSITY (US) | 2019-08-13 | — | — | US | disclosed |
| US-10023599-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | WAKE FOREST UNIVERSITY (US) | 2018-07-17 | — | — | US | disclosed |
| US-10023599-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | WAKE FOREST UNIVERSITY (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170081351-A1 | Design, Synthesis, and Biological Activity of Platinum-benz[c]acridine Hybrid Agents and Methods Associated Therewith | WAKE FOREST UNIVERSITY | 2017-03-23 | — | — | US | disclosed |
| US-20170081351-A1 | Design, Synthesis, and Biological Activity of Platinum-benz[c]acridine Hybrid Agents and Methods Associated Therewith | WAKE FOREST UNIVERSITY | 2017-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023599-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | ACR, TP53, MCL1 | HSD17B10 1554/4885WDR5 2406/4885MEN1 1372/4885 |
| US-10377784-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | ACR, TP53, BAD | HSD17B10 1374/4885WDR5 2259/4885MEN1 1481/4885 |
| US-20170081351-A1 | Design, Synthesis, and Biological Activity of Platinum-benz[c]acridine Hybrid Agents and Methods Associated Therewith | ACR, TP53, MCL1 | HSD17B10 1554/4885WDR5 2406/4885MEN1 1372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.