Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.64 |
| ▸ | RAD52 | P43351 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | TTR | P02766 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | BCHE | P06276 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | DHFR | P00374 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12018980 | 0.90 | POLB (0.53) | POLBRAD52KMT2AGAAKDM4E | |
| SCHEMBL4868213 | 0.80 | MEN1 (0.79) | POLBKMT2AKDM4EMAPTCYP1A2 | |
| SCHEMBL4867646 | 0.79 | ACHE (0.58) | KMT2AGAABCHEACHECYP1A2 | |
| SCHEMBL4865297 | 0.79 | ACHE (0.57) | KMT2AGAABCHEACHECYP1A2 | |
| SCHEMBL5104517 | 0.78 | ACHE (0.58) | KMT2AGAABCHEACHECYP1A2 | |
| SCHEMBL10061506 | 0.78 | POLB (0.64) | POLBRAD52KMT2AGAAKDM4E | |
| SCHEMBL4867391 | 0.77 | EGFR (0.67) | POLBKDM4ECYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL5107785 | 0.77 | PDE5A (0.61) | KMT2AGAABCHEACHECYP1A2 | |
| SCHEMBL1868598 | 0.77 | RAD52 (1.00) | POLBRAD52KMT2AGAAKDM4E | |
| SCHEMBL5104646 | 0.76 | ACHE (0.54) | KMT2AGAABCHEACHECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493857-A1 | 9-AMINOACRIDINE DERIVATIVES, THEIR PREPARATION AND USES | Ariel-University Research and Development Company Ltd. (IL) | 2012-09-05 | — | — | EP | claimed |
| US-20120220537-A1 | 9-AMINOACRIDINE DERIVATIVES, THEIR PREPARATION AND USES | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2012-08-30 | — | — | US | claimed |
| WO-2011051950-A1 | 9-AMINOACRIDINE DERIVATIVES, THEIR PREPARATION AND USES | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD (IL) | 2011-05-05 | — | — | WO | claimed |
| EP-2493857-A1 | 9-AMINOACRIDINE DERIVATIVES, THEIR PREPARATION AND USES | Ariel-University Research and Development Company Ltd. (IL) | 2012-09-05 | — | — | EP | disclosed |
| US-20120220537-A1 | 9-AMINOACRIDINE DERIVATIVES, THEIR PREPARATION AND USES | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2012-08-30 | — | — | US | disclosed |
| US-20120220537-A1 | 9-AMINOACRIDINE DERIVATIVES, THEIR PREPARATION AND USES | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2012-08-30 | — | — | US | disclosed |
| WO-2011051950-A1 | 9-AMINOACRIDINE DERIVATIVES, THEIR PREPARATION AND USES | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD (IL) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011051950-A1 | 9-AMINOACRIDINE DERIVATIVES, THEIR PREPARATION AND USES | ARIEL-UNIVERSITY RESEARCH AND DEVELOPMENT COMPANY LTD (IL) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220537-A1 | 9-AMINOACRIDINE DERIVATIVES, THEIR PREPARATION AND USES | MPG, PRMT9, AADAT | POLB 842/4885RAD52 1372/4885KMT2A 848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.