Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1870513 | 0.87 | ADORA1 (0.58) | ADORA1DRD2ADORA2BADORA3 | |
| SCHEMBL1871730 | 0.79 | ADORA1 (0.40) | ADORA1DRD2ALOX5APFEN1DRD4 | |
| SCHEMBL1871234 | 0.78 | ADORA1 (0.47) | ADORA1DRD2DRD4ADORA2BADORA3 | |
| SCHEMBL1875007 | 0.77 | ADORA1 (0.55) | ADORA1DRD2ADORA2BADORA3ADORA2A | |
| SCHEMBL1866092 | 0.77 | PDE5A (0.33) | MAOBMAOAALOX5APFEN1SIGMAR1 | |
| SCHEMBL1866939 | 0.77 | ADORA1 (0.44) | ADORA1ADORA2BHSD11B1ADORA3ADORA2A | |
| SCHEMBL1870359 | 0.76 | ADORA1 (0.44) | ADORA1ADORA2BHSD11B1ADORA3ADORA2A | |
| SCHEMBL1871420 | 0.76 | ADORA1 (0.41) | ADORA1ADORA2BADORA3ADORA2A | |
| SCHEMBL1868348 | 0.76 | ADORA1 (0.58) | ADORA1ADORA2BADORA2A | |
| SCHEMBL1866236 | 0.75 | ADORA1 (0.41) | ADORA1ADORA2BALDH1A1ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499142-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | Advinus Therapeutics Limited (IN) | 2012-09-19 | — | — | EP | claimed |
| WO-2011055391-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2011-05-12 | — | — | WO | claimed |