Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 7/20 | 0.58 |
| ▸ | PDE9A | O76083 | 3/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1871541 | 0.82 | HTT (0.44) | ADORA1GAAPOLB | |
| SCHEMBL1872803 | 0.82 | ADORA1 (0.59) | ADORA1PDE9AP2RX7GAAMAPT | |
| SCHEMBL1871663 | 0.78 | TP53 (0.45) | ADORA1PDE9AP2RX7TP53GAA | |
| SCHEMBL1865267 | 0.76 | ADORA1 (0.44) | ADORA1ADORA2AADORA2B | |
| SCHEMBL1887812 | 0.74 | ADORA2B (0.39) | ADORA1ADORA2AADORA2B | |
| SCHEMBL12079015 | 0.73 | ADORA1 (1.00) | ADORA1ADORA2AADORA2B | |
| SCHEMBL1871730 | 0.72 | ADORA1 (0.40) | ADORA1ADORA2AADORA2B | |
| SCHEMBL1868311 | 0.72 | ADORA1 (0.34) | ADORA1ADORA2AADORA2B | |
| SCHEMBL1870248 | 0.70 | ADORA3 (0.39) | ADORA1ADORA2AADORA2B | |
| SCHEMBL1871164 | 0.70 | ADORA1 (0.45) | ADORA1TP53ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499142-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | Advinus Therapeutics Limited (IN) | 2012-09-19 | — | — | EP | claimed |
| WO-2011055391-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2011-05-12 | — | — | WO | claimed |