Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 11/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14879935 | 0.84 | CNR1 (0.49) | CNR1CNR2HSD11B1CDK5CDK5R1 | |
| SCHEMBL28879200 | 0.82 | CNR1 (0.49) | CNR1CNR2HSD11B1CDK5CDK5R1 | |
| SCHEMBL29805447 | 0.78 | CNR1 (0.46) | CNR1CNR2HSD11B1CDK5CDK5R1 | |
| SCHEMBL23451255 | 0.78 | ADORA2A (0.55) | CNR1CNR2HSD11B1CDK5CDK5R1 | |
| SCHEMBL18654609 | 0.75 | CNR1 (0.40) | CNR1CNR2HSD11B1CDK5CDK5R1 | |
| SCHEMBL2566436 | 0.72 | HSD11B1 (0.64) | CNR1HSD11B1AOC3 | |
| SCHEMBL22146027 | 0.72 | NUDT1 (0.47) | CNR1CNR2HSD11B1TYK2 | |
| SCHEMBL2950708 | 0.70 | CNR1 (0.45) | CNR1CNR2HSD11B1CDK5CDK5R1 | |
| SCHEMBL23599390 | 0.69 | NPC1 (0.49) | CNR1CNR2AOC3 | |
| SCHEMBL20688213 | 0.68 | CNR1 (0.44) | CNR1CNR2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |