Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 15/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | AADAT | Q8N5Z0 | 3/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654416 | 1.00 | NTRK1 (0.33) | NTRK1PIK3C3AADATPDE10A | |
| SCHEMBL18654651 | 0.84 | DPP4 (0.36) | NTRK1 | |
| SCHEMBL18654639 | 0.83 | NTRK1 (0.40) | NTRK1 | |
| SCHEMBL14897796 | 0.79 | GRM5 (0.39) | NTRK1PIK3C3 | |
| SCHEMBL14897395 | 0.78 | LMNA (0.43) | NTRK1 | |
| SCHEMBL14897150 | 0.78 | AADAT (0.34) | NTRK1PIK3C3AADATPDE10A | |
| SCHEMBL14897815 | 0.78 | AADAT (0.34) | NTRK1PIK3C3AADATPDE10A | |
| SCHEMBL18654835 | 0.78 | ALDH1A1 (0.33) | — | |
| SCHEMBL14897147 | 0.78 | NTRK1 (0.39) | NTRK1 | |
| SCHEMBL18654695 | 0.77 | CACNA1H (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |