Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654872 | 0.79 | IRAK4 (0.47) | IRAK4HSD17B10KMT2AMEN1CREBBP | |
| SCHEMBL18654864 | 0.78 | IRAK4 (0.47) | IRAK4KMT2AMEN1CREBBPPOLB | |
| SCHEMBL14897370 | 0.78 | IRAK4 (0.52) | IRAK4CSNK1DCSNK1EPIM1KMT2A | |
| SCHEMBL14897258 | 0.77 | IRAK4 (0.48) | IRAK4CSNK1DCSNK1EHSD17B10PIM1 | |
| SCHEMBL20355593 | 0.77 | IRAK4 (0.53) | IRAK4KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL21765953 | 0.76 | IRAK4 (0.50) | IRAK4HSD17B10KMT2ACREBBPALDH1A1 | |
| SCHEMBL14897731 | 0.75 | IRAK4 (0.46) | IRAK4CSNK1DCSNK1EALDH1A1SMN1; SMN2 | |
| SCHEMBL14897368 | 0.75 | IRAK4 (0.46) | IRAK4KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL14897256 | 0.74 | IRAK4 (0.46) | IRAK4CSNK1DCSNK1EKMT2AMEN1 | |
| SCHEMBL21637243 | 0.73 | HTT (0.47) | IRAK4HSD17B10PIM1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |