Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654872 | 0.82 | IRAK4 (0.47) | IRAK4HTTSMN1; SMN2EPHB3KMT2A | |
| SCHEMBL18654870 | 0.78 | IRAK4 (0.48) | IRAK4SMN1; SMN2EPHB3KMT2AMEN1 | |
| SCHEMBL21765953 | 0.77 | IRAK4 (0.50) | IRAK4HTTSMN1; SMN2KMT2APOLB | |
| SCHEMBL20355593 | 0.77 | IRAK4 (0.53) | IRAK4HTTSMN1; SMN2EPHB3KMT2A | |
| SCHEMBL14897370 | 0.75 | IRAK4 (0.52) | IRAK4EPHB3KMT2AMEN1 | |
| SCHEMBL14897368 | 0.74 | IRAK4 (0.46) | IRAK4SMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL14897258 | 0.74 | IRAK4 (0.48) | IRAK4SMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL14897731 | 0.74 | IRAK4 (0.46) | IRAK4HTTSMN1; SMN2EPHB3 | |
| SCHEMBL21637243 | 0.74 | HTT (0.47) | IRAK4HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL21765821 | 0.74 | IRAK4 (0.48) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |