Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 12/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14896706 | 0.86 | TGFBR1 (0.42) | TGFBR1ATRKMO | |
| SCHEMBL14897233 | 0.86 | KMO (0.39) | TGFBR1ATRKMOHDAC1MKNK1 | |
| SCHEMBL14896955 | 0.85 | TGFBR1 (0.44) | TGFBR1ATRKMO | |
| SCHEMBL14897827 | 0.85 | TGFBR1 (0.40) | TGFBR1ATRKMOMKNK1CHRM4 | |
| SCHEMBL14896775 | 0.85 | CHRNB2 (0.45) | TGFBR1ATRKMO | |
| SCHEMBL18654515 | 0.85 | TGFBR1 (0.45) | TGFBR1ATRKMOHDAC1MKNK1 | |
| SCHEMBL14897192 | 0.84 | TGFBR1 (0.46) | TGFBR1ATRKMOHDAC1CHRM4 | |
| SCHEMBL14896826 | 0.84 | TGFBR1 (0.56) | TGFBR1 | |
| SCHEMBL14897200 | 0.84 | TSHR (0.43) | TGFBR1ATRKMOCDK2 | |
| SCHEMBL14897297 | 0.84 | CYP1A2 (0.42) | TGFBR1ATRKMOMKNK1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |