Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 10/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654405 | 0.87 | TGFBR1 (0.39) | FYNTGFBR1 | |
| SCHEMBL18654753 | 0.86 | FYN (0.42) | FYNDYRK1ATGFBR1SCN10ARIPK1 | |
| SCHEMBL18654863 | 0.83 | RIPK1 (0.37) | FYNDYRK1ASCN10ARIPK1 | |
| SCHEMBL14896687 | 0.80 | TGFBR1 (0.44) | FYNDYRK1ATGFBR1SCN10A | |
| SCHEMBL14897179 | 0.79 | TGFBR1 (0.48) | FYNDYRK1ATGFBR1SCN10ARORC | |
| SCHEMBL16265189 | 0.79 | FYN (0.47) | FYNDYRK1ATGFBR1SCN10ARORC | |
| SCHEMBL14897184 | 0.79 | DYRK1A (0.43) | FYNDYRK1ATGFBR1SCN10A | |
| SCHEMBL14897471 | 0.79 | DYRK1A (0.43) | FYNDYRK1ATGFBR1SCN10A | |
| SCHEMBL14897001 | 0.78 | TGFBR1 (0.47) | FYNDYRK1ATGFBR1SCN10ARIPK1 | |
| SCHEMBL14896776 | 0.78 | SCN10A (0.43) | FYNDYRK1ATGFBR1SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |