Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | RAD52 | P43351 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30253677 | 0.83 | POLB (0.66) | POLBRAD52RAB9AKDM4EMITF | |
| SCHEMBL617240 | 0.83 | POLB (0.66) | POLBRAD52RAB9AKDM4EMITF | |
| SCHEMBL18655356 | 0.82 | LRRK2 (0.47) | KDM4ELMNAALDH1A1GLAGAA | |
| SCHEMBL18631798 | 0.82 | POLB (0.49) | POLBRAD52RAB9AKDM4EMITF | |
| SCHEMBL21250747 | 0.76 | POLB (0.45) | POLBRAD52RAB9AKDM4EMITF | |
| SCHEMBL7880366 | 0.75 | POLB (0.78) | POLBRAD52RAB9AKDM4EMITF | |
| SCHEMBL15867122 | 0.74 | POLB (0.68) | POLBRAD52RAB9AKDM4EMITF | |
| SCHEMBL18655351 | 0.72 | POLR1A (0.44) | POLBRAD52RAB9AKDM4EMITF | |
| SCHEMBL18655366 | 0.70 | HDAC3 (0.40) | RAB9AKDM4ELMNAKMT2ANPC1 | |
| SCHEMBL18655361 | 0.70 | MAPT (0.39) | RAB9AKDM4EKMT2ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377784-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | WAKE FOREST UNIVERSITY (US) | 2019-08-13 | — | — | US | disclosed |
| US-10023599-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | WAKE FOREST UNIVERSITY (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170081351-A1 | Design, Synthesis, and Biological Activity of Platinum-benz[c]acridine Hybrid Agents and Methods Associated Therewith | WAKE FOREST UNIVERSITY | 2017-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023599-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | ACR, TP53, MCL1 | POLB 308/4885RAD52 1051/4885RAB9A 1022/4885 |
| US-10377784-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | ACR, TP53, BAD | POLB 284/4885RAD52 973/4885RAB9A 1053/4885 |
| US-20170081351-A1 | Design, Synthesis, and Biological Activity of Platinum-benz[c]acridine Hybrid Agents and Methods Associated Therewith | ACR, TP53, MCL1 | POLB 308/4885RAD52 1051/4885RAB9A 1022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.