Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLR1A | O95602 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 5/20 | 0.40 |
| ▸ | RAD52 | P43351 | 5/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18631798 | 0.91 | POLB (0.49) | POLR1ACYP1A2KDM4EALDH1A1MAPT | |
| SCHEMBL18631799 | 0.79 | ACHE (0.44) | KDM4EALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL18650739 | 0.79 | L3MBTL1 (0.47) | CYP1A2ALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL18631802 | 0.79 | ACHE (0.44) | KDM4EALDH1A1HPGDMAPTPOLB | |
| SCHEMBL30253677 | 0.76 | POLB (0.66) | KDM4EALDH1A1POLBRAD52KMT2A | |
| SCHEMBL617240 | 0.76 | POLB (0.66) | KDM4EALDH1A1POLBRAD52KMT2A | |
| SCHEMBL21250745 | 0.74 | RAD52 (0.48) | POLR1ACYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL14388990 | 0.72 | RAD52 (0.75) | ALDH1A1POLBRAD52HRH1KMT2A | |
| SCHEMBL18655368 | 0.72 | POLB (0.48) | KDM4EALDH1A1MAPTPOLBRAD52 | |
| SCHEMBL11668990 | 0.70 | CA12 (0.65) | KDM4EALDH1A1HPGDMAPTHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377784-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | WAKE FOREST UNIVERSITY (US) | 2019-08-13 | — | — | US | disclosed |
| US-10023599-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | WAKE FOREST UNIVERSITY (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170081351-A1 | Design, Synthesis, and Biological Activity of Platinum-benz[c]acridine Hybrid Agents and Methods Associated Therewith | WAKE FOREST UNIVERSITY | 2017-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023599-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | ACR, TP53, MCL1 | POLR1A 389/4885CYP1A2 1469/4885KDM4E 4196/4885 |
| US-10377784-B2 | Design, synthesis, and biological activity of platinum-benz[c]acridine hybrid agents and methods associated therewith | ACR, TP53, BAD | POLR1A 428/4885CYP1A2 1417/4885KDM4E 4210/4885 |
| US-20170081351-A1 | Design, Synthesis, and Biological Activity of Platinum-benz[c]acridine Hybrid Agents and Methods Associated Therewith | ACR, TP53, MCL1 | POLR1A 389/4885CYP1A2 1469/4885KDM4E 4196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.