Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.67 |
| ▸ | SNCA | P37840 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | RECQL | P46063 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.67 |
| ▸ | APEX1 | P27695 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | CNR1 | P21554 | 2/20 | 0.67 |
| ▸ | RAD52 | P43351 | 2/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.55 |
| ▸ | MMP2 | P08253 | 4/20 | 0.55 |
| ▸ | MMP7 | P09237 | 4/20 | 0.55 |
| ▸ | MMP14 | P50281 | 4/20 | 0.55 |
| ▸ | MET | P08581 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12188003 | 0.82 | BACE1 (0.72) | BACE1SNCAKDM4EMAPTRECQL | |
| SCHEMBL22769206 | 0.82 | BACE1 (0.72) | BACE1SNCAKDM4EMAPTRECQL | |
| SCHEMBL12379706 | 0.82 | BACE1 (0.72) | BACE1SNCAKDM4EMAPTRECQL | |
| SCHEMBL20991943 | 0.81 | DYRK1A (0.64) | BACE1SNCAKDM4EMAPTRECQL | |
| Gallocatechin SCHEMBL3872234 | 0.80 | BACE1 (1.00) | BACE1SNCAKDM4EMAPTRECQL | |
| Epigallocatechin SCHEMBL20203645 | 0.80 | BACE1 (1.00) | BACE1SNCAKDM4EMAPTRECQL | |
| Epigallocatechin SCHEMBL1972940 | 0.80 | BACE1 (1.00) | BACE1SNCAKDM4EMAPTRECQL | |
| Epigallocatechin SCHEMBL12285364 | 0.80 | BACE1 (1.00) | BACE1SNCAKDM4EMAPTRECQL | |
| Epigallocatechin SCHEMBL19553 | 0.80 | BACE1 (1.00) | BACE1SNCAKDM4EMAPTRECQL | |
| Epigallocatechin SCHEMBL1972938 | 0.80 | BACE1 (1.00) | BACE1SNCAKDM4EMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10420815-B2 | Combinational therapy for synergistic inhibition of gram-positive and gram-negative bacteria | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2019-09-24 | — | — | US | disclosed |
| WO-2017045060-A1 | COMBINATIONAL THERAPY FOR SYNERGISTIC INHIBITION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2017-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10420815-B2 | Combinational therapy for synergistic inhibition of gram-positive and gram-negative bacteria | NRDC, BPGM, TGM3 | BACE1 2908/4885SNCA 4588/4885KDM4E 4202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.