Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 3/20 | 0.52 |
| ▸ | CASP7 | P55210 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18655578 | 0.86 | MAPT (0.53) | MAPTL3MBTL1TDP1CYP1A2CYP3A4 | |
| SCHEMBL18655577 | 0.85 | MAPT (0.67) | MAPTL3MBTL1TDP1CYP1A2CYP3A4 | |
| SCHEMBL17274925 | 0.84 | MAPT (0.54) | MAPTL3MBTL1TDP1CYP1A2CYP3A4 | |
| SCHEMBL17274876 | 0.84 | MAPT (0.45) | MAPTL3MBTL1TDP1CYP1A2CYP3A4 | |
| SCHEMBL1921824 | 0.77 | PSEN1 (0.57) | MAPTMAPK1LMNAKDM4ERAB9A | |
| SCHEMBL1921889 | 0.76 | ALDH1A1 (0.60) | MAPTL3MBTL1TDP1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9706065 | 0.75 | MAPT (0.69) | MAPTL3MBTL1TDP1CYP1A2CYP3A4 | |
| SCHEMBL19271263 | 0.74 | MAPT (0.65) | MAPTL3MBTL1TDP1CYP1A2CYP3A4 | |
| SCHEMBL27165249 | 0.73 | TOP2A (0.56) | MAPTL3MBTL1TDP1CYP1A2CASP1 | |
| SCHEMBL17274871 | 0.72 | POLB (0.56) | MAPTL3MBTL1TDP1CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170081328-A1 | AZA-ELLIPTICINE ANALOGS, METHODS OF SYNTHESIS AND METHODS OF TREATMENT | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2017-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170081328-A1 | AZA-ELLIPTICINE ANALOGS, METHODS OF SYNTHESIS AND METHODS OF TREATMENT | AZI2, DNMT1, TET3 | MAPT 3584/4885L3MBTL1 4845/4885TDP1 1327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.