Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 3/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18477663 | 0.72 | HTR2C (0.38) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL13992539 | 0.70 | HTR2A (0.41) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL3406995 | 0.68 | CYP3A4 (0.45) | CYP3A4HTR2CHTR2AHTR2BADRB1 | |
| SCHEMBL24385162 | 0.68 | HTR2C (0.41) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL22942898 | 0.67 | HTR2C (0.35) | CYP3A4HTR2CHTR2AHTR2BADRB1 | |
| SCHEMBL3429458 | 0.66 | CYP11B2 (0.39) | SLC6A2SLC6A4MEN1KMT2ACYP2A6 | |
| SCHEMBL91997 | 0.62 | — | — | |
| SCHEMBL31556280 | 0.62 | — | — | |
| SCHEMBL23784132 | 0.62 | MAOA (0.51) | — | |
| SCHEMBL13242322 | 0.62 | HTR2C (0.53) | CYP3A4HTR2CHTR2AHTR2BADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3144303-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | Array Biopharma, Inc. (US) | 2017-03-22 | — | — | EP | disclosed |