Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 3/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10159222 | 0.89 | DRD2 (0.30) | MAPTMEN1USP2KMT2AKDM4E | |
| SCHEMBL10159246 | 0.89 | DRD2 (0.30) | MAPTMEN1USP2KMT2AKDM4E | |
| SCHEMBL10159233 | 0.89 | DRD2 (0.30) | MAPTMEN1USP2KMT2AKDM4E | |
| SCHEMBL18250130 | 0.82 | RAPGEF4 (0.30) | — | |
| SCHEMBL18250140 | 0.82 | RAPGEF4 (0.30) | — | |
| SCHEMBL18250136 | 0.82 | RAPGEF4 (0.30) | — | |
| SCHEMBL10159133 | 0.80 | MAPT (0.33) | MAPTMEN1USP2KMT2AGAA | |
| SCHEMBL10159296 | 0.80 | MAPT (0.33) | MAPTMEN1USP2KMT2AGAA | |
| SCHEMBL10159221 | 0.80 | MAPT (0.33) | MAPTMEN1USP2KMT2AGAA | |
| SCHEMBL18656955 | 0.78 | MAPT (0.50) | MAPTMEN1USP2KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3144299-A1 | PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | Cambria Pharmaceuticals, Inc. (US) | 2017-03-22 | — | — | EP | disclosed |