SCHEMBL1865829

SCHEMBL1865829

Cc1cc(Br)cn2c(C=O)cnc12

nearest known ligand 0.42

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.42
RXFP1 Q9HBX9 1/20 0.38
HSD17B10 Q99714 1/20 0.36
ALDH1A1 P00352 1/20 0.33
PRNP P04156 1/20 0.33
HTR6 P50406 1/20 0.33
PABPC1 P11940 2/20 0.31
TRPA1 O75762 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25157109 0.81 ALDH1A1 (0.33) HSD17B10ALDH1A1
SCHEMBL19781524 0.78 L3MBTL1 (0.49) L3MBTL1RXFP1HSD17B10PRNPHTR6
SCHEMBL29956028 0.77 ALDH1A1 (0.33) HSD17B10ALDH1A1HTR6
SCHEMBL19781523 0.75 L3MBTL1 (0.46) L3MBTL1RXFP1HSD17B10PRNPHTR6
SCHEMBL31155609 0.72 L3MBTL1 (0.44) L3MBTL1RXFP1HSD17B10PRNPHTR6
SCHEMBL1870362 0.71 PIK3CB (0.32) ALDH1A1TRPA1
SCHEMBL22438547 0.71 L3MBTL1 (0.42) L3MBTL1RXFP1PRNPHTR6PABPC1
SCHEMBL29955904 0.71 ERN1 (0.34) HSD17B10ALDH1A1TRPA1
SCHEMBL24632396 0.71 ATM (0.31) ALDH1A1
SCHEMBL1047966 0.70 ALDH1A1 (0.41) HSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8741932-B2 Imidazopyridine derivatives Piramal Enterprises Limited (IN) 2014-06-03 US disclosed
US-20120232072-A1 IMIDAZOPYRIDINE DERIVATIVES PIRAMAL LIFE SCIENCES LIMITED (IN) 2012-09-13 US disclosed
WO-2011055320-A1 IMIDAZOPYRIDINE DERIVATIVES PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-05-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120232072-A1 IMIDAZOPYRIDINE DERIVATIVES IL6, IL6ST, STAT3 L3MBTL1 4847/4885RXFP1 1653/4885HSD17B10 4429/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.