Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 9/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20756988 | 1.00 | OPRL1 (0.38) | OPRL1OPRM1DPP4OPRK1KDM2B | |
| SCHEMBL16980439 | 0.96 | DPP4 (0.41) | OPRL1OPRM1DPP4OPRK1KDM2B | |
| SCHEMBL27290705 | 0.94 | DPP4 (0.44) | OPRL1OPRM1DPP4OPRK1OPRD1 | |
| SCHEMBL20756242 | 0.91 | OPRL1 (0.40) | OPRL1OPRM1DPP4OPRK1OPRD1 | |
| SCHEMBL20757013 | 0.89 | ALDH1A1 (0.36) | OPRL1OPRM1OPRK1KDM2BMEN1 | |
| SCHEMBL20756943 | 0.88 | MEN1 (0.37) | OPRL1OPRM1DPP4OPRK1SIGMAR1 | |
| SCHEMBL760258 | 0.86 | OPRM1 (0.46) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL25481370 | 0.85 | OPRL1 (0.39) | OPRL1OPRM1DPP4OPRK1OPRD1 | |
| SCHEMBL14519149 | 0.85 | ALDH1A1 (0.36) | OPRL1OPRM1DPP4OPRK1KDM2B | |
| SCHEMBL14519158 | 0.85 | MEN1 (0.38) | OPRL1OPRM1DPP4OPRK1KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017045751-A1 | COMPOUNDS AS ASIC INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | WO | disclosed |