Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.55 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7777272 | 0.76 | F2 (0.55) | F2PRSS1PRSS2PRSS3MMP2 | |
| SCHEMBL7770967 | 0.76 | F2 (0.55) | F2PRSS1PRSS2PRSS3MMP2 | |
| SCHEMBL4658355 | 0.76 | F2 (0.57) | F2PRSS1PRSS2PRSS3MMP2 | |
| SCHEMBL7303158 | 0.76 | F2 (0.55) | F2PRSS1PRSS2PRSS3MMP2 | |
| SCHEMBL28574997 | 0.75 | HTR6 (0.50) | MMP2CA1CA2MMP1MMP9 | |
| SCHEMBL12784309 | 0.74 | F2 (0.59) | F2PRSS1PRSS2PRSS3MMP2 | |
| SCHEMBL1124662 | 0.73 | F2 (0.52) | F2PRSS1PRSS2PRSS3MMP2 | |
| SCHEMBL5795166 | 0.72 | MMP2 (0.50) | F2PRSS1PRSS2PRSS3MMP2 | |
| SCHEMBL2170132 | 0.72 | CA1 (0.50) | F2PRSS1PRSS2PRSS3MMP2 | |
| SCHEMBL25376416 | 0.71 | F2 (0.50) | F2PRSS1PRSS2PRSS3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017048675-A1 | SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-03-23 | — | — | WO | disclosed |